Chapter 9c: asymmetric synthesis – formation of optically-pure compounds

There are two ways to obtain such compounds. The first method is called the resolution in which the reactants we are starting with are either racemic or achiral. We separate the enantiomers after the production of both enantiomers. This method is vastly used in industries even if it doubles the volumes. They try to use […]

Chapter 9b: asymmetric synthesis – analytical methods of determination of the enantiomeric excess

A chiral agent is always necessary to differentiate the enantiomers. The most used methods to determine the ee are the GC with a chiral stationnary phase, HPLC with a chiral stationnary phase, NMR with chiral lanthanides. Gazeous chromatography The stationnary phase of the column is chiral and only composed of one enantiomer (for instance the […]